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Bhagwat, Durgacharan A.
- Analytical and Bio Analytical Method for Quantification of Pure Azilsartan, Not its Salts by RP-HPLC
Abstract Views :179 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, M. S., IN
2 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, M. S., IN
1 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, M. S., IN
2 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, M. S., IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1131-1137Abstract
A simple, specific and accurate reverse phase liquid chromatographic method was developed for determination of Azilsartan in its tablet dosage form as well as from biological fluid like plasma. The determination was carried out on ODS Hypersil C18 column (4.6 mm x 250 mm 5μm) column using a mobile phase of acetonitrile: water (pH 4) [60: 40 %v/v]. The flow rate was 1 mL/min with detection at 249 nm. The linearity response of the HPLC system for Azilsartan was obtained over the range 1-64 μg/mL. Ambroxol (25μg/mL) was used as internal standard. Retention time for Azilsartan and ambroxol were found to be 3.74 and 1.84 minutes respectively. The correlation co-efficient (R2 value) for Azilsartan was found to be 0.992. The proposed method was successfully used for quantification of Azilsartan in Azilva tablets and plasma. The method was validated as per ICH Q2B (Analytical) and USFDA (Bio-analytical) guidelines. The results of analysis have been validated statistically and by recovery studies. The method is found useful for quantification of Azilsartan in marketed formulations as well as from biological fluids and can be applied for quantification of Azilsartan in preclinical and clinical studies.Keywords
Azilsartan, Ambroxol, RP-HPLC, Plasma, ICH Q2B, Bioanalytical Method.- Analytical and Bioanalytical Method for Quantification of Pure Azilsartan, Not its Salts by RP-HPLC
Abstract Views :158 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, M. S., IN
2 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, M. S., IN
1 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, M. S., IN
2 Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Near Chitranagari, Kolhapur-416013, M. S., IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 708-714Abstract
A simple, specific and accurate reverse phase liquid chromatographic method was developed for determination of Azilsartan in its tablet dosage form as well as from biological fluid like plasma. The determination was carried out on ODS Hypersil C18 column (4.6 mm x 250 mm 5μm) column using a mobile phase of acetonitrile: water (pH 4) [60: 40 %v/v]. The flow rate was 1 mL/min with detection at 249 nm. The linearity response of the HPLC system for Azilsartan was obtained over the range 1-64 μg/mL. Ambroxol (25μg/mL) was used as internal standard. Retention time for Azilsartan and ambroxol were found to be 3.74 and 1.84 minutes respectively. The correlation co-efficient (R2 value) for Azilsartan was found to be 0.992. The proposed method was successfully used for quantification of Azilsartan in Azilva tablets and plasma. The method was validated as per ICH Q2B (Analytical) and USFDA (Bio-analytical) guidelines. The results of analysis have been validated statistically and by recovery studies. The method is found useful for quantification of Azilsartan in marketed formulations as well as from biological fluids and can be applied for quantification of Azilsartan in preclinical and clinical studies.Keywords
Azilsartan, Ambroxol, RP-HPLC, Plasma, ICH Q2B, Bioanalytical Method.- Application of Seed Polymer Extracted from Benincasa hispida for Development of Fast Dissolving Tablet of Carvedilol
Abstract Views :145 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
2 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
3 Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
1 Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
2 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
3 Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 9, No 3 (2017), Pagination: 167-172Abstract
Natural polymers are preferred over synthetic polymers as they are nontoxic, facilely available at low cost, utilized in low concentration, and are naturally extracted to provide nutritional supplement. Fast dissolving tablets have received ever-increasing demand during the last decade. Aim of present study was to develop fast dissolving tablet of Carvedilol using seed polymer extracted from Benincasa hispida. Prepared tablets were evaluated for pre and post compression parameters. Results of compatibility study using FTIR and DSC showed that Carvedilol is compatible with extracted seed polymer. Pre-compression studies revealed good micromeritic properties of powder blend for direct compression. In-vitro dissolution study showed that, tablet containing seed polymer released 90.67% of drug within 60 min. Study concluded that, natural superdisintegrant extracted from Benincasa hispida can be efficaciously utilized in tablet formulations which exhibit faster drug dissolution and hence may increase bioavailability, thereby, availing in efficacious therapy with improved patient compliance.Keywords
Benincasa hispida, Seed Polymer, Natural Superdisintegrant, Fast Dissolving Tablet, Carvedilol.References
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